Ankyrin-like motif-based peptides for the treatment of cancer

Details Ankyrin-like motif-based peptides for the treatment of cancer Ankyrin-like motif-based peptides for the treatment of cancer

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 9/127 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 47/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/46 (2006.01)

Patent

CA 2650113

Synthetic peptides containing an ankyrin repeat-like motif or portion thereof and mimetics thereof which interact with synuclein-gamma (SNCG) and reduce SNCG- mediated resistance of SNCG-expressing cancer cells to treatment with anticancer drugs or inhibit tumorigenesis and cancer cell proliferation are provided. Compositions containing these peptides, portions thereof or mimetics thereof are also provided. Methods for use of these peptides or portions thereof, compositions, and mimetics thereof in potentiating efficacy of anticancer drugs, in particular microtubule inhibitors and hormonal cancer therapies, and in treating cancer are also provided.

L'invention concerne des peptides de synthèse contenant un motif de type ankyrine répété, ou des parties ou des mimétiques de tels peptides, qui interagissent avec la synucléine-gamma (SNCG) et réduisent la résistance, médiée par SNCG, des cellules cancéreuses exprimant SNCG au traitement par des médicaments anticancéreux, ou empêchent la tumorogenèse et la prolifération des cellules cancéreuses. L'invention concerne également des compositions contenant lesdits peptides ou des parties ou mimétiques desdits peptides, ainsi que des procédés d'utilisation desdits peptides ou parties desdits peptides, de compositions et de mimétiques desdits peptides afin de renforcer l'efficacité de médicaments anticancéreux, en particulier les inhibiteurs microtubulaires et les thérapies hormonales, et de traiter les cancers.

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