Annellated 4-(indazolyl)-1,4-dihydropyridine derivatives and...

Details Annellated 4-(indazolyl)-1,4-dihydropyridine derivatives and... Annellated 4-(indazolyl)-1,4-dihydropyridine derivatives and...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/538 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2727199

This invention relates to novel annellated 4-(indazolyl)-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.

La présente invention concerne de nouveaux dérivés condensés de la 4-(indazolyl)-1,4-dihydropyridine ayant une activité inhibitrice des protéines tyrosine kinases, un procédé permettant de les fabriquer et leur utilisation dans le traitement de maladies médiées par c-Met ou détats médiés par c-Met, particulièrement le cancer et autres affections prolifératives.

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