C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 47/42 (2006.01) A61K 49/00 (2006.01)
Patent
CA 2633033
The present invention provides methods and compositions for the treatment and diagnosis of diseases such as neoplastic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and inflammatory diseases. The methods are based on the concept of pretargeting and include the administration of complexes comprising a recognizable compound A coupled to annexins, and the administration of complexes comprising of pharmaceutical or diagnostic compounds coupled to a compound B recognizing and binding to compound A to subjects. The compositions include annexins, annexin variants, that are not internalized by the target cells, derivatives thereof, and complexes thereof.
La présente invention concerne des procédés et des compositions pour le traitement et le diagnostic de maladies telles que des maladies néoplasiques, des maladies neurodégénératives, des maladies cardiovasculaires, des maladies auto-immunes, et des maladies inflammatoires. Les procédés sont basés sur le concept de préciblage et comprennent l'administration de complexes comprenant un composé A reconnaissable couplé à des annexines, et l'administration à des sujets de complexes comprenant des composés pharmaceutiques ou diagnostiques couplés à un composé B reconnaissant et se liant au composé A. Les compositions comprennent des annexines, des variants d'annexine, qui ne sont pas internalisés par les cellules cibles, des dérivés de celles-ci, et des complexes de celles-ci.
Moonen Peter
Reutelingsperger Christiaan Peter Maria
Vermaire Ad
Mosamedix B.v.
Ridout & Maybee Llp
LandOfFree
Annexin derivatives suitable for pretargeting in therapy and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Annexin derivatives suitable for pretargeting in therapy and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Annexin derivatives suitable for pretargeting in therapy and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2037147