Annexin v-binding polypeptides derived from hbsag and their...

Details Annexin v-binding polypeptides derived from hbsag and their... Annexin v-binding polypeptides derived from hbsag and their...

C - Chemistry, Metallurgy

07

K

C07K 14/02 (2006.01) A61K 39/29 (2006.01) C07K 16/08 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2274585

Polypeptides derived from hepatitis B surface antigen which are able to compete with the hepatitis B surface antigen/annexin V interaction, or which are able to bind a compound or antibody competing with the hepatitis B surface antigen/annexin V interaction are described. The use of these polypeptides, and antibodies against them, in order to diagnose, treat and vaccinate against an infection with hepatitis B virus and/or hepatitis delta virus is also disclosed.

L'invention a pour objet des polypeptides dérivés de l'antigène de surface de l'hépatite B. Ces polypeptides peuvent agir par compétition avec l'interaction de l'antigène de surface de l'hépatite B/annexine V ou peuvent se lier à un composé ou un anticorps agissant par compétition avec l'interaction de l'antigène de surface de l'hépatite B/annexine V. L'invention traite également de ces polypeptides, et des anticorps de ces derniers dans le diagnostic, le traitement et la vaccination contre une infection par le virus de l'hépatite B et/ou le virus de l'hépatite de delta.

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