C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 51/00 (2006.01) C07K 17/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2572707
The present invention provides methods and compositions for the treatment, diagnosis, and prevention of diseases, such as neoplastic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and inflammatory diseases. The methods include the administration of pharmaceutical complexes comprising annexins coupled to pharmaceutical compounds or carriers to subjects. The present invention also provides methods and compositions for delivering therapeutic compounds into the diseased cells of a subject either to kill them, such as tumor cells, or to rescue them, such as cardiomyocytes and neurons. The compositions include annexins, annexin variants, derivatives thereof, and complexes thereof.
La présente invention concerne des méthodes et des compositions pour le traitement, le diagnostic et la prévention de maladies, telles que les maladies néoplasiques, les maladies neurodégénératives, les maladies cardiovasculaires, les maladies auto-immunes et les maladies inflammatoires. Lesdites méthodes font appel à l'administration de complexes pharmaceutiques comprenant des annexines couplées à des composés ou à des supports pharmaceutiques à des sujets. La présente invention concerne également des méthodes et des compositions permettant d'administrer des composés thérapeutiques dans les cellules malades d'un sujet afin de tuer, par exemple, les cellules tumorales, ou afin de préserver, par exemple, les cardiomyocytes et les neurones. Lesdites compositions comprennent des annexines, des variantes d'annexines, des dérivés de ces dernières, ainsi que des complexes de ces dernières.
Goudreau Gage Dubuc
I.p. Randwijck B.v.
Mosamedix B.v.
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