Anorexigenic peptides

Details Anorexigenic peptides Anorexigenic peptides

C - Chemistry, Metallurgy

07

K

530/5.06, 530/5.

C07K 5/08 (2006.01)

Patent

CA 1189066

ANOREXIGENIC PEPTIDES Abstract There are disclosed peptides of the formula A-B-C and pharmaceutically acceptable salts thereof, in which A is selected from the group consisting of L-pyroglutamyl, D-pyroglutamyl, and L-homo-pyroglutamyl; B is selected from the group consisting of L-histidyl, L-3'-methylhistidyl, D-histidyl, L-phenylalanyl, L-p-aminophenylalanyl,and L-.beta.-(pyrazolyl-1)alanyl; and C is selected from the group consisting of glycine and lower alkyl esters thereof, glycinamide and lower alkyl amides thereof, 2-amino-1-hydroxyethyl, D-alanine, L-.beta.-(2-thienyl)- alanine, and NHR1 in which R1 is lower alkyl, with/the proviso that C may not be glycine or glycinamide when A is L-pyroglutamyl and B is L-histidyl. The compounds have anorexigenic properties, in- hibit excessive gastric and pancreatic secretion, and cause activation in the CNS. Methods for their preparation and use are also disclosed.

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