Ansamycin derivatives as antioncogene and anticancer agents

Details Ansamycin derivatives as antioncogene and anticancer agents Ansamycin derivatives as antioncogene and anticancer agents

C - Chemistry, Metallurgy

07

D

C07D 225/06 (2006.01) A61K 31/395 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 405/12 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2166320

A compound of formula (I) and pharmaceutically acceptable salts and prodrugs thereof wherein R1, R2, R3, R4, R5 and R6 are as defined below, methods and intermediates useful in the preparation thereof, pharmaceutical compositions thereof and methods of treatment therewith. The compounds of formula (I) are useful in inhibiting oncogene products and as antitumor and anticancer agents.

L'invention se rapporte à un composé de formule (I) dans laquelle R<1>, R<2>, R<3>, R<4>, R<5> et R<6> ont la définition figurant dans la définition, ainsi qu'à ses sels et promédicaments pharmaceutiquement acceptables; l'invention se rapporte également aux procédés et produits intermédiaires servant à la préparation dudit composé, à ses compositions pharmaceutiques et aux méthodes de traitement l'utilisant. Les composés de formule (I) sont utiles pour l'inhibition des produits d'oncogènes ainsi qu'en tant qu'agents antitumoraux et anticancéreux.

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