Ansamycins having improved pharmacological and biological...

Details Ansamycins having improved pharmacological and biological... Ansamycins having improved pharmacological and biological...

C - Chemistry, Metallurgy

07

D

C07D 233/14 (2006.01) A61K 31/33 (2006.01) C07D 225/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07F 9/553 (2006.01)

Patent

CA 2474508

Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.

L'invention concerne des ansamycines et des procédés de préparation et d'utilisation desdites ansamycines. Certaines de ces ansamycines possèdent au moins une ou plusieurs des propriétés suivantes: aptitude à la formulation aqueuse améliorée, stabilité chimique et biodisponibilité. Certains des dérivés décrits sont des dimères. Ces dérivés ainsi que d'autres peuvent comprendre un ou plusieurs groupes de solubilisation dont l'utilité attendue est de rendre possible l'utilisation de la totalité de ces composés comme médicaments et promédicaments.

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