Antagonism of endothelin actions

Details Antagonism of endothelin actions Antagonism of endothelin actions

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/14 (2006.01) A61P 15/10 (2006.01)

Patent

CA 2391818

The mechanism of hypertension following acute NO synthase blockade is via endothelin-mediated vasoconstriction. Thus, NO appears to inhibit endothelin activity by blocking its expression and not as a chronic direct acting vasodilator. Administration of an endothelin antagonist to a patient in a 'normal' physiological state may result in specific regional vasodilation. This treatment finds utility in the treatment of erectile dysfunction.

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