C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/44 (2006.01) A61K 31/47 (2006.01) A61K 31/4706 (2006.01) A61K 31/4709 (2006.01) A61K 31/473 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 37/06 (2006.01) C07D 215/233 (2006.01) C07D 215/42 (2006.01) C07D 215/46 (2006.01) C07D 219/12 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2412345
The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods comprise compounds that are analogs and derivatives of chloroquine, such as 4-aminoquinolines, and other weak bases. They can be used in preventative and therapeutic treatments of autoimmune diseases and phenomena, transplant rejection such as host-versus- graft disease, and sepsis.
L'invention concerne le domaine de l'immunologie en général et, plus précisément, des compositions et des procédés permettant d'inhiber la stimulation du système immunitaire. Les composés et les procédés comprennent des composés analogues et dérivés de la chloroquine, tels que des 4-aminoquinolines et autres bases faibles. Ces composés peuvent être utilisés pour les traitements préventifs et thérapeutiques de maladies et de phénomènes auto-immuns, de rejet de greffon tel que la réaction du greffon contre l'hôte, et la sepsie.
Barlin Gordon B.
Ismail Fyaz
Macfarlane Donald E.
Manzel Lori
Strekowski Lucjan
Australian National University
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Georgia State University Research Foundation Inc.
The United States Of America As Represented By The Department Of Veterans Affairs
University Of Iowa Research Foundation
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