C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01)
Patent
CA 2649907
Stable liquid pharmaceutical compositions comprising an antagonist anti- CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody -containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and/or inflammatory component.
La présente invention a pour objet des compositions pharmaceutiques liquides stables comprenant un anticorps anti-CD40 antagoniste au titre de principe actif thérapeutique ou prophylactique, ainsi que des méthodes pouvant être employées pour leur élaboration. Ces compositions comprennent l'anticorps anti-CD40 antagoniste, un agent tampon pour maintenir le pH de la composition entre environ 5,0 et environ 7,0, et une quantité d'arginine-HCl suffisante pour rendre la composition liquide quasiment isotonique. Les compositions pharmaceutiques stables liquides contenant l'anticorps anti-CD40 antagoniste selon l'invention trouvent des applications dans des méthodes de traitement de maladies prolifératives et de maladies à composante auto-immune et/ou inflammatoire.
Araya Kidisti
Chen Bao-Lu
Lu Xiaofeng
Okhamafe Augustus
Borden Ladner Gervais Llp
Novartis Ag
Xoma Technology Ltd.
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