C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/12 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2670992
The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
La présente invention concerne des anticorps antagonistes qui se lient spécifiquement à Notch 3 et qui inhibent son activation. Cette invention concerne des anticorps qui se lient à un épitope conformationnel comprenant le premier domaine Lin12 et le deuxième domaine de dimérisation et concerne également les utilisations de ces anticorps pour traiter ou prévenir les maladies ou les troubles liés à Notch 3.
Fung Sek Chung
Li Kang
Li Yucheng
Singh Sanjaya
Zhou Bin-Bing Stephen
Genentech Inc.
Smart & Biggar
LandOfFree
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