C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61P 3/00 (2006.01) A61P 21/00 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2619491
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
L'invention concerne de nouvelles molécules associées au facteur -8 de croissance et de différenciation (GDF-8), en particulier des anticorps de souris et des anticorps humanisés, ainsi que des fragments d'anticorps, y compris ceux qui inhibent l'activité et la signalisation de GDF-8 in vitro ou in vivo. Elle concerne également des méthodes servant à diagnostiquer, traiter, améliorer, prévenir, pronostiquer ou contrôler des troubles dégénératifs des muscles, des os et du métabolisme de l'insuline, en particulier, la sclérose latérale amyotrophique (ALS). Elle concerne, de plus, des compositions pharmaceutiques servant à traiter ces troubles au moyen de ces anticorps, polypeptides, polynucléotides et vecteurs.
Holzbaur-Howland Erika L.f.
Howland David S.
Karim Riyez
Kelley Pamela
Kwak Seung Poon
The Trustees Of The University Of Pennsylvania
Torys Llp
Wyeth
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