Antagonist antibodies directed against calcitonin...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/26 (2006.01) A61K 39/395 (2006.01) A61P 25/06 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2626120

The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.

Procédés pour la prévention ou le traitement de troubles associés au peptide lié au gène de la calcitonine, du type symptômes vasomoteurs, y compris la céphalée (par exemple, migraine, algie vasculaire de la face, et céphalée de tension associée à la migraine) et les bouffées de chaleur, reposant sur l'administration d'un anticorps antagoniste vis-à-vis du peptide considéré. On décrit aussi des anticorps antagonistes G1 et des anticorps dérivés de ces anticorps G1 orientés contre le peptide susmentionné.

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