C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 19/02 (2006.01) A61P 27/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C12N 5/20 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2404576
This invention relates to antibodies, or immunologically active fragments thereof, specific for the N-terminal 15 amino acids of a mammalian VE-cadherin and which act as antagonists of VE-cadherin-mediated homophilic interactions between adjacent endothelial cells without adversely affecting normal vasculature. In a preferred embodiment, the antibodies are humanized antibodies directed that react with human VE-cadherin for use in a human. The invention also provides pharmaceutical compositions comprising these antibodies and antibody fragments, methods of preparing the antibodies, and methods of using the antibodies and antibody fragments to inhibit angiogenesis, inhibit tumor metastasis, or treat cell proliferative disorders.
L'invention concerne des anticorps ou des fragments à activité immunologique de ces anticorps, lesquels anticorps et fragments sont spécifiques des acides aminés 15 N-terminaux de la VE-cadhérine d'un mammifère et agissent comme antagonistes d'interactions homophiles induites par la VE-cadhérine entre des cellules endothéliales adjacentes sans avoir d'effets défavorables sur le système vasculaire. Dans un mode de réalisation préféré, ces anticorps sont des anticorps humanisés et dirigés qui réagissent avec la VE-cadhérine humaine afin d'être utilisés sur un être humain. L'invention concerne également des compositions pharmaceutiques comprenant ces anticorps et ces fragments d'anticorps, des procédés de préparation et d'utilisation de ces anticorps et de ces fragments d'anticorps afin d'inhiber l'angiogenèse et la métastase tumorale ou de traiter les troubles de la prolifération cellulaire.
Bohlen Peter
Hicklin Daniel J.
Liao Fang
Gowling Lafleur Henderson Llp
Imclone Llc
Imclone Systems Incorporated
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