Antagonist of melanin-concentrating hormone receptor...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 235/30 (2006.01) A61K 31/4184 (2006.01) A61K 31/4196 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2

Patent

CA 2494102

Benzimidazole derivative of the general formula: [I] wherein each of B1, B2 and B3 represents a hydrogen atom or a lower alkyl; R1 and R2 may be identical with or different from each other and represent lower alkyls, etc.; each of R3 and R4 represents a hydrogen atom, etc.; W represents a 3 to 8-membered aromatic or aliphatic heterocycle, etc.; and Ar represents a substituted or unsubstituted aromatic heterocycle, etc. This compound functions as an antagonist of melanin-concentrating hormone receptor and is useful as a drug for central diseases, circulatory diseases and metabolic diseases.

L'invention concerne un dérivé de benzimidazole représenté par la formule (I) dans laquelle chaque B?1¿, B?2¿ et B?3¿ représente un atome d'hydrogène ou un alkyle inférieur ; R?1¿ et R?2¿ peuvent être identiques ou différents et représentent des alkyles inférieurs, etc. ; chaque R?3¿ et R?4¿ représente un atome d'hydrogène, etc. ; W représente un hétérocycle aromatique ou aliphatique à 3 à 8 éléments, etc. ; et Ar représente un hétérocycle aromatique substitué ou non substitué, etc. Ce composé sert d'antagoniste d'un récepteur d'hormone concentrant de la mélanine et est utile en tant que médicament pour les maladies du système nerveux central, les maladies du système circulatoire et les maladies métaboliques.

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