C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2679399
The present invention relates to antagonist antibodies directed against human OX40 receptor (CD 134) and fragments thereof, including the amino acid sequences of antagonist antibodies and the nucleic acids that encode the antibodies. Also included in the present invention are antigen binding regions (CDRs) derived from the light and/or heavy chain variable regions of said antibodies. Another aspect of the present invention is the use of anti-OX40 antagonist antibodies in the treatment of inflammatory and autoimmune diseases. The present invention also relates to humanized sequences of an antagonist antibody AlO and epitope mapping of the binding site of the antibody.
La présente invention concerne des anticorps antagonistes concernant un récepteur OX40 humain (CD 134) et des fragments de celui-ci, y compris les séquences d'acides aminés d'anticorps antagonistes et les acides nucléiques qui codent les anticorps. L'invention concerne également des zones de liaison à un antigène (CVR) déduites des zones variables à chaîne légère et/ou lourde des anticorps. Un autre aspect de la présente invention est l'utilisation d'anticorps antagonistes anti-OX40 dans le traitement de maladies inflammatoires et auto-immunes. La présente invention concerne également les séquences humanisées d'un anticorps antagoniste d'AlO, et une cartographie d'épitopes du site de liaison de l'anticorps.
Lamhamedi-Cherradi Salah-Eddine
Singh Sanjaya
Yao Zhengbin
Genetech Inc.
Smart & Biggar
LandOfFree
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