Antagonistic analogs of gh-rh inhibiting igf-i and -ii

Details Antagonistic analogs of gh-rh inhibiting igf-i and -ii Antagonistic analogs of gh-rh inhibiting igf-i and -ii

C - Chemistry, Metallurgy

07

K

C07K 14/60 (2006.01) A61K 38/25 (2006.01) A61P 5/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2351665

There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2. These analogs inhibit the activity of endogenous hGH-RH, and therefore prevent the relase of growth hormone. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.

La présente invention concerne une nouvelle série d'analogues synthétiques de hGH-RH(1-29)NH2. Ces analogues inhibent l'activité de hGH-RH endogène, et empêchent ainsi la libération de l'hormone de croissance. La puissante action inhibitrice de ces nouveaux analogues, par rapport à ceux déjà décrits, est due au remplacement de nombreux acide aminés.

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