C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2452447
Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b (e.g., KD = 10-8 M or less), a slow off rate for TNFSF13b dissociation (e.g., Koff = 10-3 sec-1 or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies of the invention are useful in one embodiment for inhibiting TNFSF13b activity in a human subject suffering from a disorder in which hTNFSF13b activity is detrimental. Nucleic acids encoding the antibodies of the present invention, as well as, vectors and host cells for expressing them are also encompassed by the invention.
La présente invention concerne des anticorps humains monoclonaux de liaison spécifique aux polypeptides TNFSF13b. Ces anticorps présente une affinité élevée pour le hTNFSF13b (par exemple K¿D? = 10?-8¿M ou moins), une vitesse lente pour la dissociation de TNFSF13b (par exemple, K¿off? = 10?-3¿ sec?-1 ¿ou moins) et neutralisent l'activité de TNFSF13b in vitro et in vivo. Les anticorps de l'invention sont utiles dans un mode de réalisation pour l'inhibition de l'activité de TNFSF13b chez un sujet humain atteint d'un trouble dans lequel une activité de hTNFSF13b est nuisible. L'invention concerne également des acides nucléiques codant pour les anticorps de la présente invention, ainsi que des vecteurs et des cellules hôtes permettant leur expression.
Gelfanova Valentina Pavlovna
Hale John Edward
Kikly Kristine Kay
Rathnachalam Radhakrishnan
Witcher Derrick Ryan
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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