Antagonists il-15

Details Antagonists il-15 Antagonists il-15

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/54 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/24 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2502316

The invention relates to fusion proteins consisting of a wild-type IL-15 and a IgG-Fc fragment, apart from a mouse IgG2b fragment, nucleic acids encoding said proteins, vectors, modified cells, and also to the use thereof for preparing drugs which are used, for example for preventing and/or curing disorders resulting from a transplantation and/or autoimmune diseases.

La présente invention concerne des protéines de fusion composées d'un IL-15 de type sauvage et d'un fragment IgG-Fc, à l'exception d'un fragment IgG2b-Fc de souris, des acides nucléiques qui codent pour ces protéines, des vecteurs, des cellules modifiées et leur utilisation pour la préparation de médicaments destinés par exemple à prévenir et/ou à traiter des troubles résultant d'une transplantation et/ou des maladies auto-immunes.

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