C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2724525
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding por-tion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particu-larly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of BMP9 and/or BMP10, ligands for ALK1, may also be used to inhibit angiogenesis in vivo.
Sous certains aspects, la présente invention est fondée sur l'idée qu'un polypeptide renfermant une partie de liaison à un ligand du domaine extracellulaire du polypeptide d'activine-like kinase I (ALK1) peut être utilisé pour inhiber l'angiogenèse in vivo, en particulier chez des mammifères souffrant de troubles se rapportant à l'angiogenèse. Sous certains aspects, l'invention démontre que des antagonistes de BMP9 et/ou BMP10 et des ligands pour ALK1 peuvent également être utilisés pour inhiber l'angiogenèse in vivo.
Grinberg Asya
Knopf John
Kumar Ravindra
Pearsall Robert S.
Seehra Jasbir
Acceleron Pharma Inc.
Smart & Biggar
LandOfFree
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