Antagonists of factor viii interaction with low-density...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/755 (2006.01) A61K 38/37 (2006.01) A61K 39/395 (2006.01) A61P 7/04 (2006.01) C07K 16/36 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2484155

The present invention concerns the use of peptides derived from and antibodies generated against Factor VIII and the inhibition of Factor VIII interaction with LRP. Furthermore, the present invention concerns a method to inhibit LRP interaction with Factor VIII as well as a method to decrease Factor VIII degradation and/or prolong Factor VIII half-life in a biological fluid and/or a method to treat patients suffering from a blood coagulation disorder, especially Haemophilia A. The present invention also concerns a pharmaceutical composition useful for the decrease of Factor VIII degradation in a biological fluid, the inhibition of Factor VIII interaction with LRP, and/or the prolongation of Factor Vlll half-life in a biological fluid for treatment of a blood coagulation disorder, especially Haemophilia A.

La présente invention concerne l'utilisation de peptides dérivés du facteur VIII et d'anticorps engendrés contre le facteur VIII et l'inhibition de l'interaction du facteur VIII avec LRP. En outre, cette invention a trait à une méthode permettant d'inhiber une interaction LRP avec le facteur VIII, ainsi qu'à une méthode servant à diminuer la dégradation du facteur VIII et/ou à prolonger la demi-vie du facteur VIII dans un fluide biologique et/ou à une méthode permettant de traiter des patients souffrant d'un trouble de coagulation sanguine, notamment, l'hémophilie A. Ladite invention a aussi pour objet une composition pharmaceutique utilisée afin de diminuer la dégradation du facteur VIII dans un fluide biologique, d'inhiber l'interaction du facteur VIII avec LRP, et/ou de prolonger la demi-vie du facteur VIII dans un fluide biologique dans le but de traiter un trouble de coagulation sanguine, notamment, l'hémophilie A.

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