C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/96 (2006.01)
Patent
CA 2359926
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of an HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk or exhibit sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.
La présente invention concerne une composition et une méthode pharmaceutiques de traitement de septicémie, notamment du choc septique et de l'IRA (insuffisance respiratoire aiguë), consistant à administrer une dose efficace d'antagoniste de HMG1. En outre, cette invention concerne une méthode diagnostique servant à mesurer la gravité ou le potentiel de létalité de la septicémie ou du choc septique, consistant à mesurer la concentration sérique du HMG1 chez un patient présentant, ou susceptible de présenter, des symptômes de septicémie ou de choc septique. Enfin, cette invention concerne une composition et une méthode pharmaceutiques destinées à la perte de poids ou au traitement de l'obésité, consistant à administrer une dose efficace de HMG1 ou un fragment de HMG1 actif sur le plan thérapeutique.
Tracey Kevin J.
Wang Haichao
North Shore-Long Island Jewish Research Institute
Osler Hoskin & Harcourt Llp
LandOfFree
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