Antagonists of human gamma interferon

Details Antagonists of human gamma interferon Antagonists of human gamma interferon

C - Chemistry, Metallurgy

07

K

C07K 14/57 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/24 (2006.01) C07K 16/42 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2092541

2092541 9206115 PCTABS00011 Novel synthetic polypeptides having amino acid sequences corresponding to the sequence of one or more specific regions of human gamma interferon are provided by this invention. These polypeptides specifically inhibit the binding of human gamma interferon to cellular receptors and the biological activity of such interferon. Antibody antagonists of the binding of human gamma interferon to cellular receptors based upon the use of the polypeptides as antigens are also provided. Some of these antagonists bind to specific regions of gamma interferon which are believed to be involved in interactions between the interferon and its receptors. Other antibody antagonists are anti-idiotypic antibodies which appear to compete directly with gamma interferon for binding to the cellular receptors. Also provided are methods for the use of the polypeptides and antibodies as inhibitors of the binding of gamma interferon to its cellular receptors.

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