Antagonists of human interleukin-6 that are totally...

Details Antagonists of human interleukin-6 that are totally... Antagonists of human interleukin-6 that are totally...

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 31/70 (2006.01) A61K 38/20 (2006.01) A61K 48/00 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2218372

The present invention relates to antagonists of human interleukin-6 that are totally incapable of binding the receptor chain responsible for transduction of the signal associated with this cytokine, that is to say with gp 130. The figure shows the lack of interaction between human interleukin-6 antagonists according to the invention and the protein gp 130.

Antagonistes de l'interleukine-6 humaine totalement incapables de se lier à la chaîne réceptrice responsable de la transduction du signal associé à cette cytokine, c'est-à-dire à la gp130. La figure illustre l'absence d'interaction entre les antagonistes de l'interleukine-6 humaine selon cette invention et la protéine gp130.

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