Antagonists of interleukin-15

Details Antagonists of interleukin-15 Antagonists of interleukin-15

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 38/16 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 47/48 (2006.01) A61P 37/06 (2006.01) C07K 14/54 (2006.01) C07K 17/00 (2006.01) C07K 17/08 (2006.01) C07K 17/10 (2006.01) C12N 15/24 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2637795

Antagonists of mammalian interleukin-15 ("IL-15") are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R.alpha.--subunit and that are incapable of transducing a signal through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.

L'invention a pour objet les antagonistes de l'interleukin-15 ("IL-15") mammaire et comprend les mutéines de molécules IL-15 et de molécules modifiées IL-15 qui sont chacune capables de se lier à la sous-unité alpha IL-15R et qui sont incapables de transduire un signal par le truchement des sous-unités bêta ou gamma du complexe récepteur IL-15. L'invention comprend également des anticorps monoclonaux contre l'IL-15 qui empêche que ce dernier effectue une transduction de signal par l'entremise des sous-unités bêta ou gamma du complexe récepteur Il-15. L'invention porte également sur des procédés pour traiter diverses maladies, notamment le rejet de greffe allogénique et la réaction immunitaire de rejet de greffe.

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