Antagonists of mcp-1 function and methods of use thereof

Details Antagonists of mcp-1 function and methods of use thereof Antagonists of mcp-1 function and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 319/18 (2006.01) A61K 31/357 (2006.01) A61P 29/00 (2006.01) C07D 215/48 (2006.01) C07D 241/42 (2006.01) C07D 265/36 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2439849

The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.

L'invention concerne des composants chimiques, des préparations pharmaceutiques comprenant lesdits composants, des utilisations desdits composants et desdites préparations, des procédés de traitement employant lesdits composants et lesdites préparations et des procédés de préparation desdits composants. Cette invention concerne en particulier de nouveaux composants qui sont des antagonistes de la fonction MCP-1 et servent à prévenir ou traiter des maladies chroniques, aiguës ou auto-immunes, en particulier celles associées à l'accumulation anormale de lymphocytes ou monocytes comme l'arthrite, l'asthme, l'athérosclérose, la néphropathie diabétique, les maladies intestinales inflammatoires, la maladie de Crohn, la sclérose en plaque, la néphrite, la pancréatite, la fibrose pulmonaire, le psoriasis, la resténose et le rejet de transplantation. L'invention concerne également des préparations pharmaceutiques comprenant ces composants et l'utilisation de ces composants et préparations dans la prévention ou le traitement de ces maladies.

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