C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) C12N 9/64 (2006.01)
Patent
CA 2669424
Antagonists of human proprotein convertase subtilisin-kexin type 9 ("PCSK9") are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
L'invention concerne des antagonistes de la proprotéine convertase humaine subtilisine/kexine de type 9 ("PCSK9"). Ces antagonistes sont efficaces pour inhiber la fonction de PCSK9 et, ainsi, sont utiles pour traiter des troubles associés à l'activité de PCSK9. L'invention concerne également de l'acide nucléique codant ces antagonistes, des vecteurs, des cellules hôtes, et des compositions comprenant de tels antagonistes. L'invention concerne également des procédés de fabrication d'antagonistes spécifiques à PCSK9, ainsi que des procédés d'utilisation de ces antagonistes pour inhiber ou pour or antagoniser la fonction de PCSK9, lesquels procédés constituant un aspect supplémentaire important de l'invention.
Condra Jon H.
Hammond Holly A.
Pandit Shilpa
Sitlani Ayesha
Sparrow Carl P.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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