Antagonists of pcsk9

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/40 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2667869

Antagonists of human proprotein convertase subtilisin-kexin type 9 ("PCSK9") are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

La présente invention concerne des antagonistes de la proprotéine convertase humaine subtilisine-kexine de type 9 ("PCSK9"). Ces antagonistes sont efficaces pour inhiber la fonction PCSK9, et, par conséquent, se présentent comme des antagonistes souhaités pour être utilisés dans le traitement des pathologies associées à l'activité PCSK9. Cette invention porte également sur de l'acide nucléique codant lesdits antagonistes, des vecteurs, des cellules hôtes et des compositions comprenant les antagonistes. Des procédés de production d'antagonistes à spécificité PCSK9 ainsi que des procédés d'utilisation de ces antagonistes pour inhiber la fonction PCSK9 ou pour assurer un effet antagoniste à cette fonction PCSK9 sont également présentés et constituent des aspects additionnels importants de la présente invention.

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