Antagonists of the magnesium binding defect as therapeutic...

Details Antagonists of the magnesium binding defect as therapeutic... Antagonists of the magnesium binding defect as therapeutic...

C - Chemistry, Metallurgy

07

C

C07C 237/22 (2006.01) A61K 31/165 (2006.01)

Patent

CA 2418951

This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of magnesium to the plasma membranes of their cells. These methods consist of administering to a mammal in need of such treatment a compound selected from a series of distributed trans, trans 1,3-butadienes, 1, 3-disubstituted perhydrobutadienes, 1,2-disubstituted trans ethylenes and 1,2-disubstituted ethanes and disubstituted propanes, each of which embodies, in common, the unique structural feature essential for the biological activity if these compounds. This invention also provides for pharmaceutical formulations that employ these novel compounds.

L'invention concerne une catégorie de composés thérapeutiques et des méthodes de traitement de mammifères atteints de troubles physiologiques, telles qu'un type fréquent d'hypertension artérielle essentielle, qui sont associées, de manière critique, à la fixation décroissante de magnésium dans les membranes plasmiques de leurs cellules. Ces méthodes consistent à administrer à un mammifère nécessitant un tel traitement un composé sélectionné parmi une série de trans, de trans-1,3 butadiènes disubstitués, de perhydrobutadiènes disubstitués en 1,3, de trans éthylènes disubstitués en 1,2 et d'éthanes disubstitués en 1,2 et de propanes disubstitués, chacun présentant, en commun, la caractéristique unique de structure essentielle pour l'activité biologique de ces composés. Cette invention concerne également des formulations pharmaceutiques faisant appel à ces nouveaux composés.

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