Antagonists of the trpv1 receptor and uses thereof

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 275/32 (2006.01) A61K 31/17 (2006.01) A61K 31/353 (2006.01) A61K 31/47 (2006.01) A61P 25/04 (2006.01) C07D 215/42 (2006.01) C07D 311/58 (2006.01)

Patent

CA 2672196

The present application is directed to compounds that are TRPV1 antagonists and have formula: (I); wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

L'invention concerne des composés qui sont des antagonistes de TRPV1 ayant la formule (I) : dans laquelle les variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2 et Y3 sont définies dans la description, des composés utiles pour le traitement de troubles provoqués ou exacerbés par l'activité du récepteur vanilloïde.

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