Antagonists of the vanilloid receptor subtype 1 (vr1) and...

Details Antagonists of the vanilloid receptor subtype 1 (vr1) and... Antagonists of the vanilloid receptor subtype 1 (vr1) and...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/416 (2006.01)

Patent

CA 2647256

The present invention is directed to compounds of formula (I), wherein variables X1, X2, Y, R1a, R1b, R2a, R2b, A1, A2, A3, and A4 are as defined in the description, and methods of use to treat pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.

Cette invention concerne des composés représentés par la formule (1), dans laquelle les variables X1, X2, Y, R1a, R1b, R2a, R2b, A1, A2, A3, et A4 sont telles que définies dans la description. Cette invention concerne également des méthodes d'utilisation permettant de traiter la douleur, la douleur neuropathique, l'allodynie, la douleur associée à une inflammation ou à une maladie inflammatoire, l'hyperalgésie inflammatoire, l'hyperactivité vésicale et l'incontinence urinaire.

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