Antagonists to the vanilloid receptor subtype 1 (vr1) and...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 13/00 (2006.01) A61P 13/10 (2006.01) A61P 29/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2590711

Compounds having formula (I) or formula (II), or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A, N, X, Y, R1, R2 and R3 are as defined in the specification. These compounds are particularly useful in the treatment of pain, inflammatory hyperalgesia, and urinary dysfunctions, such as bladder overactivity and urinary incontinence.

L'invention concerne des composés de formule (I) ou (II) ou un sel, un promédicament ou un sel d'un promédicament de ceux-ci acceptables sur le plan pharmaceutique, dans lesquelles A, N, X, Y, R1, R2 et R3 sont tels que définis dans la description. Ces composés sont spécialement utiles dans le traitement de douleurs, d'hyperalgésie inflammatoire et de dysfonctionnements urinaires, tels que la suractivité de la vessie et l'incontinence urinaire.

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