Anthelmintic composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/74 (2006.01) A61P 33/10 (2006.01)

Patent

CA 2594981

A topical formulation comprising as active ingredients, at least one effective agent derived from Streptomyces avermitilis, i.e. a macrocylic lactone e.g. an avermectin or chemically modified or synthetic derivative thereof, e.g. ivermectin, together with another anthelmintic of the sulphonamide type, e.g. clorsulon, in a carrier that facilitates topical administration and delivery of the active ingredients transdermal Iy, e.g. a carrier that is useful for this purpose comprises alcoholic solvents, such as ethanol, and isopropanol, with optional excipients and formulation aids, which may comprise a polymeric species such as PVP or a poloxamer.

La présente invention décrit une formule locale comprenant, au titre de principes actifs, au moins une substance active dérivée de Streptomyces avermitilis, c'est-à-dire une lactone macrocyclique, par exemple une avermectine ou un dérivé chimiquement modifié ou synthétique de l'avermectine, par exemple l'ivermectine, associée à un autre agent anthelminthique de type sulfonamide, par exemple la clorsulone, dans un vecteur qui facilite l'administration locale et la libération des principes actifs par voie transdermique. Un vecteur adapté à cette application comprend par exemple des solvants alcooliques, tels que l'éthanol et l'isopropanol, ainsi que des excipients et adjuvants éventuels, qui peuvent inclure une substance polymère telle que le PVP ou un poloxamère.

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