A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4184 (2006.01) A01N 43/04 (2006.01) A01N 43/52 (2006.01) A61K 9/08 (2006.01) A61P 33/10 (2006.01)
Patent
CA 2622713
This invention relates to the preparation of veterinary anthelmintic formulations including triclabendazole in solution, particularly for the treatment of parasitic infections such as fasciolisis, and particularly for administration to an animal in the form of a pour-on. The solutions include triclabendazole dissolved in a solvent system including at least one solvent selected from 2-pyrrolidone and liquid polyethylene glycol. Additional solvents may also be included. The present invention is advantageous as triclabendazole can be included in solution up to a concentration of about 60% w/v allowing for an effective dose to be delivered to the animal in a volume of 25 ml or less.
L~invention concerne la préparation de compositions aux anthelminthiques à usage vétérinaire comprenant du triclabendazole en solution, notamment destinées au traitement d~infections parasitaires, telles que la distomatose, et en particulier destinées à une administration à un animal sous la forme d~un pour-on. Les solutions comprennent du triclabendazole dissous dans un système de solvant comprenant au moins un solvant choisi entre la 2-pyrrolidone et du polyéthylène glycol liquide. Des solvants supplémentaires peuvent également être compris. La présente invention a pour avantage que du triclabendazole peut être compris dans une solution à une concentration allant jusqu~à environ 60 % du p/v permettant de délivrer une dose efficace à l~animal dans un volume de 25 ml ou moins.
Merial Limited
Smart & Biggar
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