Anthracene derivatives as anti-cancer agents

Details Anthracene derivatives as anti-cancer agents Anthracene derivatives as anti-cancer agents

C - Chemistry, Metallurgy

07

C

C07C 229/08 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) C07C 229/12 (2006.01) C07C 229/26 (2006.01) C07C 229/36 (2006.01) C07C 271/22 (2006.01) C07D 207/16 (2006.01) C07D 209/20 (2006.01) C07D 295/116 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2334797

A compound is provided having formula (I) wherein: R1 and R2 are independently hydrogen, hydroxy, alkoxy or acyloxy; R3 and R4 are independently oxo, hydroxy or hydrogen; one of R5 or R6 is A-B and the other is hydrogen, hydroxy, alkoxy, acyloxy, a group -A-B or a group -amino-R7-O-Y; the or each A is independently a spacer group having the formula -amino-R7-O- which is bonded to the anthracene ring via the amino group nitrogen and to B via the -O-atom; R7 is a divalent organic radical; B is an amino acid residue, a peptide group, or isostere thereof; and Y is hydrogen or a capping group, or a physiologically acceptable derivative thereof. The compounds primarily have utility against cancers, but also have use against viruses and parasites having topoisomerases.

L'invention porte sur un composé ayant la formule (I) dans laquelle R?1¿ et R?2¿ représentent, indépendamment, hydrogène, hydroxy, alcoxy ou acyloxy; R?3¿ et R?4¿ représentent, indépendamment, oxo, hydroxy ou hydrogène; l'un de R?5¿ ou R?6¿ représente A-B et l'autre représente hydrogène, hydroxy, alcoxy, acyloxy, un groupe -A-B ou un groupe -amino-R?7¿-O-Y; chaque A représente, indépendamment, un groupe espaceur ayant la formule -amino-R?7¿-O- qui est lié au noyau d'anthracène par l'azote du groupe amino et à B par l'atome -O-; R?7¿ est un radical organique divalent; B est un reste d'acide aminé, un groupe peptidique ou un isostère de celui-ci; et Y représente hydrogène ou un groupe coiffant, ou un dérivé physiologiquement acceptable de celui-ci. Ces composés sont utiles, principalement, pour lutter contre le cancer, mais aussi contre les virus et les parasites possédant des topoisomérases.

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