Anthracycline-antibody conjugates

Details Anthracycline-antibody conjugates Anthracycline-antibody conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2510664

The invention relates to therapeutic conjugates with the ability to target various antigens. The conjugates contain a targeting antibody or antigen binding fragment thereof and an anthracycline chemotherapeutic drug. The targeting antibody and the chemotherapeutic drug are linked via a linker comprising a hydrazide moiety.

L'invention concerne des conjugués thérapeutiques, capables de cibler divers antigènes. Les conjugués contiennent un anticorps ou un antigène cible, liant un de ses fragments et un médicament chimiothérapique d'anthracycline. L'anticorps cible et le médicament chimiothérapique sont liés par l'intermédiaire d'un agent de liaison comprenant une fraction d'hydrazide.

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