Anthracycline antineoplastic agents encapsulated in...

A - Human Necessities – 61 – K

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A61K 9/50 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) C07H 15/252 (2006.01)

Patent

CA 1272686

ABSTRACT Formulations consisting of phospholipid micellular particles encapsulating anthracycline anti-neoplastic agents and methods for using such compositions to treat neoplastic tumors are described. In a preferred embodiment, the particles are in the form of vesicles which comprise an anthracycline agent, preferably daunorubicin, distearoyl phosphatidyl choline, distearoyl phosphatidyl glycerol and cholesterol, preferably in the ratio of about 1:4:5:6 to about 1:4:20:20. The vesicles are suspended in a low ionic solution such as 5% dextrose at pH 7.4 and may be administered to humans to deliver the anthracycline to treat neoplastic tumors.

503851

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