C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
167/182, 204/91.
C07H 15/252 (2006.01) A61K 31/71 (1995.01)
Patent
CA 1340422
The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I, which are optionally in the form of a salt of an inorganic or organic acid, Image in which the substituents have the following meaning: R1 is hydrogen or a hydroxyl group, R2 is hydrogen or a hydroxyl or a methoxy group, R3 is hydrogen or a hydroxyl group, R4 is hydrogen or a hydroxyl group, R5 is hydrogen, a hydroxyl or a methoxycarbonyl group, or a substituent of the general formula II, Image in which R8a has the meaning indicated for R8, or a substituent of the formula III, -2- Image R6 is ethyl, methylcarbonyl, hydroxymethylcarbonyl, hydroxyalkyl or dihydroxyalkyl, R7 is hydrogen or a substituent of the general formula IV, Image and R3 is hydrogen or a cyanomethyl group or a substituent of the general formula COR9 or CH2R10, R9 being hydrogen, CH3, CF3 or CCl3, and R10 being C1- to C8-alkyl, substituted alkyl, phenyl or substituted phenyl, to a process for their preparation and to their use in pharmaceuticals.
553622
Berscheid Hans Gerd
Bottger Dirk
Gerken Manfred
Hermentin Peter
Hoffmann Dieter
Behringwerke Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
Anthracycline derivatives having cytostatic activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anthracycline derivatives having cytostatic activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anthracycline derivatives having cytostatic activity will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1252247