C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
167/182, 260/208
C07H 15/252 (2006.01) C07H 15/26 (2006.01)
Patent
CA 1340021
The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I, which can optionally also be in the form of an acid addition salt of physiologically acceptable inorganic or organic acids, where R1 is hydrogen or a hydroxyl group, R2 is hydrogen, a hydroxyl or a methoxy group, R3 is hydrogen or a hydroxyl group, R4 is hydrogen or a hydroxyl group, R5 is hydrogen, a hydroxyl or a methoxycarbonyl group, R6 is CH2CH3, COCH3, COCH2OH, CHOHCH3 or CHOHCH2OH and R7 is an organic substituent which has 2 to 6 carbon atoms and which contains at least one oxygen, nitrogen or sulfur atom or a C-C double bond or a C-C triple bond, it being possible for the double bond also to be a constituent of a heteroaromatic system and for the oxygen, nitrogen or sulfur atom to be a constituent of an open-chain or heterocyclic system, to a process for the preparation thereof and to the use thereof in a pharmaceutical. (see fig. I)
601592
Gerken Manfred
Hermentin Peter
Hoffmann Dieter
Kolar Cenek
Kraemr Hans Peter
Behringwerke Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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