Anthracycline glycosides

Details Anthracycline glycosides Anthracycline glycosides

C - Chemistry, Metallurgy

07

H

260/208.1

C07H 15/252 (2006.01)

Patent

CA 1248944

Abstract This invention provides compounds of the formula Image I wherein R represents a hydrogen atom, a lower alkyl, aryl or aryl-(lower alkyl) group, a 5-membered or 6-membered hetero- aromatic group in which the hetero atom is nitrogen, oxygen or sulphur or a group of the formula -(CH2)n-COR' or Image (b) R' represents a hydroxy, lower alkoxy, amino, lower alkylamino, di-(lower alkyl)- amino or arylamino group n stands for an integer of 1 to 4, n' stands for an integer of 2 to 10, R1 and R2 each repre- sent a hydrogen atom or one of R1 and R2 represents a hydrogen atom and the other represents a hydroxy, lower alkoxy or benzyloxy group and X represents a group of the formula -CH2- , Image or -CH2-CH2- (i) (ii) (iii) and pharmaceutically acceptable acid addition salts thereof, a process for their manufacture and medicaments containing them. These compounds and salts possess antitumour activity.

436376

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