C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/252 (2006.01) A61K 31/704 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2178684
Anthracycline derivatives are disclosed which are coupled to an enzymatically cleavable N-phenyl-O-glycosyl carbamate spacer group, which derivatives are represented by the formula Image as well as the acid addition salts thereof. Further the synthesis of these derivatives and their use, alone or in combination with enzymes or antibody enzyme conjugates are disclosed.
Damen Eric Wilhelmus Petrus
de Vos Dick
Haisma Hidde Jacob
Houba Pieter Herman Johannes
Leenders Ruben Gerardus George
Gowling Lafleur Henderson Llp
Pharmachemie B.v.
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