Anthracyclinone derivatives and their use in amyloidosis

Details Anthracyclinone derivatives and their use in amyloidosis Anthracyclinone derivatives and their use in amyloidosis

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) A61K 31/12 (2006.01) A61K 31/135 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/65 (2006.01) A61K 31/70 (2006.01) A61K 38/02 (2006.01) C07C 225/32 (2006.01) C07C 225/34 (2006.01) C07C 233/36 (2006.01) C07C 235/06 (2006.01) C07D 295/108 (2006.01) C07D 295/112 (2006.01) C07D 317/26 (2006.01) C07D 317/28 (2006.01)

Patent

CA 2173623

The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4 and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and pharmaceutical composition containing them are also described.

L'invention concerne la nouvelle utilisation de l'anthracyclinone de formule (A) dans le traitement de l'amylose, formule dans laquelle R¿1?, R¿2?, R¿3?, R¿4? et R¿5? sont des substituants appropriés. Certains composés de la formule (A) sont nouveaux. L'invention concerne également des procédés de préparation desdits composés ainsi qu'une composition pharmaceutique les contenant.

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