C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/18 (2006.01) C07C 311/08 (2006.01) C07C 311/29 (2006.01) C07C 311/44 (2006.01) C07D 207/335 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 213/64 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 231/12 (2006.01) C07D 231/16 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 235/14 (2006.01) C07D 235/16 (2006.01) C07D 277/28 (2006.01) C07D 277/30 (2006.01) C07D 307/14 (2006.01) C07D 307/52 (2006.01) C07D 307/54 (2006.01) C07D 405/12 (2006.01) C07D 5
Patent
CA 2445341
The invention relates to anthranilic acid amides, to a method for the production thereof, to their use as a medicament, and to pharmaceutical preparations containing these anthranilic acid amides. The anthranilic acid amides consist of compounds of formula (I) in which R(1) to (R7) have the meanings as cited in the claims, act upon the Kv1.5 potassium channel, and inhibit a potassium stream described as an "ultra-rapidly activating delayed rectifier" in the human cardiac atrium. The compounds are therefore especially suited as novel antiarrhythmic active substances, particularly for treating and preventing atrial arrhythmias, e.g. atrial fibrillation AF or atrial flutter.
La présente invention concerne des amides d'acide anthranilique, leur procédé de production, leur utilisation en tant que médicament et des préparations pharmaceutiques les renfermant. Les composés de formule (I), dans laquelle R(1) à (R7) ont les significations énoncées dans les revendications, ont une action sur le canal potassique Kv1.5 et inhibent un courant de potassium appelé <= rectifieur à retard à activation ultra-rapide >= dans l'oreillette humaine. Ces composés conviennent par conséquent particulièrement bien en tant que substances actives antiarythmisantes d'un nouveau type, notamment dans le cadre du traitement et de la prophylaxie d'arythmies auriculaires, telles que des fibrillations auriculaires ou des flutters auriculaires.
Brendel Joachim
Hemmerle Horst
Kleemann Heinz-Werner
Peukert Stefan
Pirard Bernard
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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