C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/28 (2006.01) A61K 31/165 (2006.01) C07C 227/30 (2006.01) C07C 227/32 (2006.01) C07D 207/14 (2006.01) C07D 207/48 (2006.01) C07D 211/58 (2006.01) C07D 213/40 (2006.01) C07D 235/14 (2006.01) C07D 307/22 (2006.01) C07D 317/58 (2006.01) C07D 333/20 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2328413
Compounds of formula (I) wherein R1 is hydrogen or halogen; R2 is electron withdrawing group; R3 is hydrogen, hydroxy, lower alkoxy, cycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted, unsaturated heterocycle; A is lower alkylene; R4 is lower alkoxy, substituted or unsubstituted, saturated or unsaturated heterocycle, substituted or unsubstituted amino, -CH2-R5, -CR6R7R8 wherein R6 and R7 are each independently carboxy, protected carboxy, substituted or unsubstituted carbamoyl, or substituted or unsubstituted lower alkyl, or R6 and R7 together with the carbon atom to which they are attached may form substituted or unsubstituted, saturated carbocycle, or substituted or unsubstituted, unsaturated carbocycle, and R8 is hydrogen, lower alkoxy, or substituted or unsubstituted lower alkyl; provided that when R4 is -CR6R7R8 wherein R6 and R7 are each independently substituted or unsubstituted lower alkyl, and R8 is hydrogen or lower alkyl, or when R4 is -CH2-R5, R3 should be hydrogen, hydroxy or cycloalkyl.
L'invention concerne des composés correspondant à la formule (I) dans laquelle R?1¿ est hydrogène ou halogène; R?2¿ est un groupe retirant les électrons; R?3¿ est hydrogène, hydroxy, alcoxy inférieur, cycloalkyle, aryle substitué ou non substitué, ou hétérocycle non substitué insaturé; A est alkylène inférieur; R?4¿ est alcoxy inférieur, substitué ou non substitué, hétérocycle saturé ou insaturé, amino substitué ou non substitué, -CH¿2?-R?5¿, -CR?6¿R?7¿R?8¿ dans lequel chacun des R?6¿ et R?7¿ est indépendamment carboxy, carboxy protégé, carbamoyle substitué ou non substitué ou alkyle inférieur substitué ou non substitué, ou R?6¿ et R?7¿ conjointement avec l'atome de carbone auquel ils sont attachés peuvent former un carbocycle saturé substitué ou non substitué, ou un carbocycle insaturé substitué ou non substitué, et R?8¿ est hydrogène, alcoxy inférieur ou alkyl inférieur substitué ou non substitué; à condition que R?4¿ est -CR?6¿R?7¿R?8¿ dans lequel chacun des R?6¿ et R?7¿ est indépendamment alkyle inférieur substitué ou non substitué, et R?8¿ est hydrogène ou alkyl inférieur, ou si R?4¿ est -CH¿2?-R?5¿, R?3¿ doit être hydrogène, hydroxy ou cycloalkyle.
Inoue Takayuki
Kayakiri Natsuko
Kuroda Akio
Mizutani Tsuyoshi
Oku Teruo
Fujisawa Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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