C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/04 (2006.01) A61K 31/196 (2006.01) A61P 31/14 (2006.01) C07C 235/24 (2006.01)
Patent
CA 2631024
The present invention is directed to compounds of formula (I): wherein R1 is selected from the group consisting of -C(O)R and (a), wherein R6 and R7 are independently selected from H, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or aryl, any of which may be optionally substituted, G is selected from H or hydroxyl, Y is O, NH or S, X is selected from the group consisting of H, halo, alkyl, cycloalkyl, perfluoroalkyl, alkoxy, alkylthio, amino, alkylamino, dialkylamino, and CN, and n is 0, 1, 2 or 3, or a prodrug, a pharmaceutically acceptable salt, or a pharmaceutically active metabolite thereof. This invention is also directed to compositions containing compounds of the invention and methods of using both the inventive compounds and compositions thereof to treat or prevent Hepatitis C virus infection, or to inhibit replication of a Hepatitis C virus.
La présente invention concerne des composés de formule (I) : dans laquelle R1 est choisi dans le groupe composé de -C(O)R et (a), dans laquelle R6 et R7 sont choisis indépendamment parmi H, un alkyle, un cycloalkyle, un hétérocycloalkyle, un hétéroaryle ou un aryle, l'un d'eux pouvant être facultativement substitué, G est choisi parmi H ou un hydroxyle, Y est O, NH ou S, X est choisi dans le groupe composé de H, un halo, un alkyle, un cycloalkyle, un perfluoroalkyle, un alcoxy, un alkylthio, un amino, un alkylamino, un dialkylamino et CN, et n est 0, 1, 2 ou 3, ou un promédicament, un sel pharmaceutiquement acceptable ou un métabolite pharmaceutiquement actif de ceux-ci. L'invention concerne également des compositions contenant les composés de l'invention et des procédés d'utilisation à la fois des composés de l'invention et des compositions de ceux-ci pour traiter ou prévenir une infection par le virus de l'hépatite C ou pour inhiber la réplication du virus de l'hépatite C.
Bloom Jonathan David
Curran Kevin J.
Insaf Shabana
Nittoli Thomas
Sutherland Alan Gordon
Torys Llp
Wyeth
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