C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 275/04 (2006.01) A61K 31/425 (2006.01) A61P 43/00 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2438312
Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula (VI), and pharmaceutically acceptable salts thereof, wherein R0 is -CH2-, -SO-, -O-, -SO2-, or -S-; compositions comprising the isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones, and derivatives thereof; and methods for treating or preventing a disorder alleviated by inhibiting Jun N-terminal kinase (JNK) by administering the isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones, and derivatives thereof are described herein.
L'invention concerne des isothiazoloanthrones, des isoxazoloanthrones, des isoindolanthrones, et des dérivés de ceux-ci représentés par la formule générale (VI), ainsi que des sels de ceux-ci pharmaceutiquement acceptables. Dans cette formule générale (VI), R¿0? représente -CH¿2?-, -SO-, -O-, -SO¿2?-, ou -S-. L'invention concerne également des compositions comprenant ces isothiazoloanthrones, ces isoxazoloanthrones, ces isoindolanthrones, et des dérivés de ceux-ci, ainsi que des méthodes de traitement ou de prévention d'un trouble atténué au moyen de l'inhibition de Jun N-terminal kinase (JNK) par administration de ces isothiazoloanthrones, ces isoxazoloanthrones, ces isoindolanthrones, et de dérivés de ceux-ci.
Raymon Heather K.
Sakata Steven T.
Osler Hoskin & Harcourt Llp
Signal Pharmaceuticals Inc.
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