Anti-activin a antibodies and uses thereof

Details Anti-activin a antibodies and uses thereof Anti-activin a antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/26 (2006.01) A61K 39/395 (2006.01) A61P 5/06 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2661878

The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

Cette invention concerne des compositions et des procédés associés ou découlant de protéines de liaison à anti-activine A, parmi lesquelles des anticorps. Des modes de réalisation décrits dans cette invention concernent des anticorps anti-activine A chimères humanisés entièrement humain qui se fixe l'activine A humaine, des fragments de liaison à l'activine A et des dérivés de tels anticorps, ainsi que des polypeptides de liaison à activine A comprenant de tels fragments. D'autres modes de réalisation concernent des acides nucléiques codant pour de tels anticorps, des fragments d'anticorps et des dérivés et des polypeptides, des cellules comprenant ces polynucléotides, des procédés permettant d'élaborer de tels anticorps, des fragments d'anticorps et des dérivés et des polypeptides, ainsi que des procédés permettant d'utiliser de tels anticorps, des fragments d'anticorps et des dérivés et des polypeptides, y compris des méthodes permettant de traiter ou de diagnostiquer des sujets présentant des troubles ou des affections associés à l'activine A, parmi lesquels, la cachexie liée au cancer des gonales, d'autres cancers, les rhumatismes, l'arthrite et d'autres maladies

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