Anti-addl antibodies and uses thereof

Details Anti-addl antibodies and uses thereof Anti-addl antibodies and uses thereof

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2584859

The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A.beta.-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer~s Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer~s Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid .beta. 1-42.

La présente invention a trait à des anticorps de reconnaissance différentielle de conformations multidimensionnelles de ligands diffusibles dérivés de l'amyloïde bêta, également désignés ADDL. Les anticorps de l'invention peuvent distinguer entre des extraits de cerveau humain atteints de la maladie d'Alzheimer et des témoins et sont utiles dans des procédés de détection des ADDL et le diagnostic de la maladie d'Alzheimer. Les anticorps de la présente invention permettent le blocage de la liaison des ADDL aux neurones, l'assemblage des ADDL, et la phosphorylation des protéines Tau et sont utiles dans des procédés pour la prévention et le traitement de maladies associées à des oligomères solubles de l'amyloïde bêta 1-42.

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