Anti-addl antibodies and uses thereof

Details Anti-addl antibodies and uses thereof Anti-addl antibodies and uses thereof

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2489195

The invention herein comprises antibodies that bind to amyloid beta-derived diffusible ligands (ADDLs). ADDLs comprise amyloid .szlig. protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.

L'invention concerne des anticorps qui se lient à des ligands de la démence dérivés d'amyloïde .beta. (ADDL). Ces ADDL comprennent une protéine d'amyloïde .beta. formant des structures oligomères, non fibrillaires, globulaires solubles capables d'activer des processus cellulaires spécifiques. L'invention concerne également des procédés faisant appel à des anticorps spécifiques des ADDL pour analyser la formation, la présence et la liaison à la protéine du récepteur et l'activité cellulaire des ADDL, ainsi que l'utilisation de ces anticorps pour détecter des composés qui bloquent la formation ou l'activité des ADDL, et des procédés permettant d'identifier de tels composés. L'invention concerne enfin des procédés d'utilisation des anticorps spécifiques des ADDL pour moduler la formation et/ou l'activité des ADDL, notamment dans le traitement de troubles liés à l'apprentissage et/ou à la mémoire.

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